Boris Negrutskii

українська версія
english version

Birthdate: February 14, 1957.

Degree: Dr (Habil) in Biology. Year awarded: 1999.

Degrees: Senior researcher. Year awarded: 1997.

Place of work: Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine. Present position: Head of Laboratory of Protein synthesis.

Scientific interests: Protein synthesis in higher eukaryotes, proteomics, channeling. Number of publications: 71.

Telephone: 380 44 526 4397. Fax: 380 44 526 0759. E-mail: negrutskii@imbg.org.ua

Main publications:

1. Lukash, T.O. Turkivska H.V., Negrutskii B.S., El'skaya A.V. Chaperone-like activity of mammalian elongation factor eEF1A: Renaturation of aminoacyl-tRNA synthetases. The International Journal of Biochemistry & Cell Biology. -2004 - V.36 P. 1341-1347.
2. Budkevich T.V., Timchenko A.A., Tiktopulo E.I., Negrutskii B.S., Shalak V.F., Petrushenko Z.M., Aksenov V.L., Willumeit R., Kohlbrecher J., Serdyuk I.N., El'skaya A.V. Extended conformation of mammalian translation elongation factor 1A in solution Biochemistry -2002-V.41, N.51. P.15342-15349.
3. Petrushenko Z.M., Shalak V.F., Budkevich T.V., Negrutskii B.S., El'skaya A.V. Novel complexes of mammalian translation elongation factor eEF1A*GDP with uncharged tRNA and aminoacyl-tRNA synthetase. Implications for tRNA channeling Eur. J. Biochem. - 2002. -V.269, p. 4811-4818.
4. Negrutskii B.S., Shalak V.F., Kerjan P., El'skaya A.V., Mirande M. Functional interaction of mammalian valyl-tRNA synthetase with elongation factor EF-1a in the complex with EF-1H J. Biol. Chem. 274, 8, 4545-4550, 1999
5. Negrutskii B.S., El'skaya A.V. Eukaryotic translation elongation factor 1a : structure, expression, functions, and possible role in aminoacyl-tRNA channeling Progr. Nucl. Acid Res. Mol. Biol., 60, 47-78, 1998.
6. Petrushenko Z.M., Negrutskii B.S., Ladokhin A.S.,Budkevich T.V., Shalak V.F., El'skaya A.V. Evidence for the formation of an unusual ternary complex of rabbit liver EF-1a with GDP and deacylated tRNA, FEBS Lett. 407, 13-17, 1997.
7. Negrutskii B.S., Budkevich T.V., Shalak V.F., Turkovskaya G.V., El'skaya A.V. Rabbit translation elongation factor 1a stimulates the activity of homologous aminoacyl-tRNA synthetase, FEBS Letters, 382, 18-20, 1996.
8. Negrutskii B.S., Stapulionis, R., Deutscher, M.P.Supramolecular organization of the mammalian translation system Proc. Natl. Acad. Sci. USA 91, 964-968, 1994.
9. Negrutskii B.S., Deutscher, M.P A sequestered pool of aminoacyl-tRNA in mammalian cells, Proc. Natl. Acad. Sci. USA 89, 3601-3604, 1992.
10. Negrutskii B.S., Deutscher, M.P Channeling of aminoacyl-tRNA for protein synthesis in vivo Proc. Natl. Acad. Sci. USA 88, 4991-4995, 1991.